Two things to note this morning:
1) We all register negative events more than positive events--and I mean the immediate feedback to our surrounding environment. Makes sense, given that negative stimuli (bad taste, dead body, etc) could kill us.
2) Some of us are more positive and some more negative genetically. A LOT of our personality traits are inherited and then acted out through environmental interplay.
As a quickie hypothesis based on the above, some negative traits will correspond more highly to alcohol and substance abuse.
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